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pentobarbital will decrease the level or result of tacrolimus by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.Check Closely (2)pentobarbital will reduce the level or result of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Strong CYP3A4 inducers may well minimize suvorexant effi